central dogma

created by Fluffy The Cat
(idea) by Fluffy The Cat (1.9 y) (print)   ?   (I like it!) Sat Jan 13 2001 at 19:18:42
DNA makes RNA and RNA makes protein - that is, DNA is transcribed into an RNA intermediate by RNA polymerase, and the RNA is then translated into a protein by the ribosomes. It's probably the major tenant of molecular biology, and it's even true most of the time. Reverse transcriptase messes things up a bit by reversing the first step, and not all RNA is turned into protein (it can be involved in gene regulation and the construction of riboproteins and various other fun stuff). But even so, it's a useful way to think about gene expression.
(idea) by The Alchemist (4.6 d) (print)   ?   (I like it!) 2 C!s Mon Apr 16 2001 at 12:57:32
The standard version of the central dogma is the simple:

DNA --> RNA --> Protein

described above. However, some people think that this is an oversimplification of the situation. A truer picture is shown below :

                        _______
                       |       |
             __________|Protein|_____
            |     _____|       |     |
            |    |     |_______|     |
            |    |        / \        |
            |    |       /| |\       |
            |    |        | |        |
            |    |      \ | | /      |
            |____|_______\| |/_______|____
                 |       /| |\       |    |
                 |      / | | \      |    |tRNA
                 |      __| |__      |    |ribosome   
                 |     |       |     |    |translation
                 |     |  RNA  |_____|____|
                 |     |       |     |
                 |     |_______|     |
  transcription  |        / \        |
                 |       /| |\       |
                 |        | |        |replication
                 |      \ | |        |
                 |_______\| |        |
                         /| |        |
                        / | |        |
                        __| |__      |
                       |       |   \ | /
                       |  DNA  |____\_/
                       |        ____  |
                       |_______|    | |               
                          / \       | | 
                         /| |\      | |
                          | |_______| |
                          |___________|

The problem here is the complexity of the representation. There are two types of arrow; big ones indicate 'transformations' while little ones indicate 'causation'. So the original dogma is pure transformation: from one type of molecule to another to another - the flow of information from DNA to protein. The second diagram (which I drew, but is almost certainly correct) subsumes the first - it is contained in the arrow between DNA and protein. However, the DNA is remade in the cyclic transform : both these processes are catalysed by protein.

You might argue that this is not what the central dogma should be about. That, however, is the point critics of dogmatic reductionism are trying to make (I think).

The whole picture is important.

(place) by xerces (2.2 wk) (print)   ?   (I like it!) Mon Apr 16 2001 at 13:16:27
Central Dogma is also a (fictional) place, deep underneath the headquaters of Neon Genesis Evangelion's NERV. It is where lots of secret Instrumentality stuff goes on. The liftshaft leading to it is shaped like the double helix of DNA. The lowest area is called Terminal Dogma.
(place) by Wigs (3.4 mon) (print)   ?   (I like it!) Sun Apr 22 2001 at 4:24:38
A huge underground area spreading directly below NERV HQ. Its lowermost level contains a sea of LCL and Lilith, crucified on a red cross. Incidentally, in biological terms, "Central Dogma" refers to the irreversible information flow that occurs in the transformation of DNA -> RNA -> protein.

Source: The End of Evangelion : Glossary contained within The End of Evangelion - Theatrical Program.

(idea) by Oslo (4.3 d) (print)   ?   (I like it!) 2 C!s Tue Dec 24 2002 at 5:01:47

I

This is the central dogma.


We inherit the central dogma from our parents, and we pass it to our children. It is the central dogma that drives us to do this, the central dogma that makes it possible. At the core of every human heart is the central dogma.

The most central tenet of the dogma is the notion of "I". The notion of self. The notion of unique thought.

Cogito ergo sum
But Descartes was only half right.

For there is no "I", there is only the belief of the "I", that notion that we are here, we think, we process, we are separate human beings. This is neither falseness, nor is it truth. It is.

I wake up next to you, again,
like yesterday and like tomorrow.
We are little waves on a little pond,
rippling in the morning greeting of a lazy sun.

I love. I think. I sleep. I judge. I breathe. I am.

Every dogma must have its sin. To forget the "I" is to abandon the central dogma. Because it is only after you believe "you" that anything becomes possible.


Other

This is the central dogma.


If there is "I" there must be something else. One world ends at our fingertips and another begins. That is the notion.

Because we are not everything, and we are not nothing, so there must be something else, there must be the "Other"; the mirror of one's mind reflects more than one's self. The "Other".

And thus the central dogma frames the dialectic within which we explore our lives, where we draw the threads of human society to form the knots we call individual existence, and everything else vibrates on our strings.

So let us raise our voices in song,
let us explore the harmony between us,
let us lose ourselves in the polyphonic confluence,
so that we might both know a little more.

In the "Other" we find opposition. That is the teaching.


Mind

This is the central dogma.


In the chaotic and fluid boundary of the separation drawn between the "I" and the "Other", the "Mind" takes flight. For to think is to judge, and to judge is to organize the perceptions of the "Other" according to models also gathered from the "Other", and those models must also be discerned by the "Mind". "Mind" is thus not our own nor not our own.

Red. Orange. Yellow. Green. Blue. Indigo. Violet.

"Mind" determines foolishness, "Mind" determines fact.


This is the central dogma


                  _______
                 |       |
                 |       |_________
                 |   I   |         |
                 |_______|         |
                    / \            |
                   /   \           |
                    | |            | 
                    | |            |  
                    | |            |
                  __| |__          |
                 |       |         |
                 |       |         |
                 | Mind  |         |
                 |_______|         | 
                    / \            |
                   /   \           | 
                    | |            |
                    | |            |
                    | |            |
                  __| |__          |
                 |       |       \ | /
                 |       |________\_/_      
                 | Other  _________   |
                 |_______|         |  |
                    / \            |  |
                   /   \           |  |
                    | |____________|  |
                    |_________________|

The three most central tenets of the central dogma thus interact; the Other perpetuates itself and creates the Mind; the I rests in the nest of the Mind; the notion of the I shapes the Other so that the next generation will do the same.

From whence have we come, then,
and where do we go from here?

Perhaps in the beginning, there was no central dogma, but rather a babbling of nonsense, a pool of primordial ideas. And perhaps from that randomness rose "I", which brought with it "Other", and thus created "Mind". This is not known. To plumb this mystery is to unravel the dogma; it is thus forbidden.

For every dogma must have its sin.

Every I must have its Other.

And in the end, there will be nothing. And it will be good.

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