The world is closing in. You cannot think. Your vision starts to fade. Your hands and feet are tingly, then numb. Your fingers spasm. You feel an impending sense of doom.
Snap out of it, it's all in your head!
Um, not exactly.
It's all in your physiology!
Read the panic attack nodes. The personal descriptions of the events share specific descriptions that can all be explained by a sudden decrease in the carbon dioxide in your blood. I will break down the events into specific physiologic responses, and next time you see someone in a panic attack, perhaps you will refrain from amateur psychology.
At the risk of inducing a panic attack, some biology and a teensy bit of high school chemistry will be involved. You can skip these parts and jump right into the jargon below.
Lesson Number One:
Carbon dioxide and acid
Ventilation means exchanging gases. We breathe in oxygen, use it to convert various foodstuffs into energy and growth, and produce water and carbon dioxide as by-products.
Our ventilation is controlled by the rate we breathe (respiratory rate, or breaths per minute) and by the amount of fresh air that gets deep into our lungs with each breath (tidal volume, measured in cc's). Our minute ventilation is our respiratory rate times our tidal volume:
Minute ventilation = RR X TV
It is possible to breathe quickly without hyperventilating. Watch a dog sitting on a porch on an August afternoon. Pant, pant, pant. Despite the dog's rapid breathing, it remains lucid enough to annoy the mail carrier. The dog has reduced his tidal volume; he takes small breaths, exchanging air in the upper airway, to cool himself off, with little air exchange in the deep reaches of the lungs.The air exchange occurs at the alveoli,tiny sacs at the end of the airways. The only air the blood sees is the alveolar air.
Conversely, it is possible to take deep, slow breaths, and still hyperventilate. Patients stuperous in a diabetic coma often do this. Even with normal or slow respirations, the patient may be hyperventilating.
Why would anybody, especially an unconscious person, choose to hyperventilate?
Carbon dioxide mixed with water makes carbonic acid. Breath by beath, our body controls the acid in our blood. The body, when things are normal, keeps the pH close to 7.40. Increase your minute ventilation, and your acid immediately drops (and the pH rises). Hold your breath, and you increase your acid (and your pH drops).
CO2 + H2O <-> H2O3 <-> H+ + HCO3-
Our kidneys ultimately control the amount of acid in our blood, but the kidneys, smart as they are, take a day or two to titrate the blood. The lungs have an immediate impact on your pH.
Hurry up, my eyes are glazing over...
A person in a diabetic coma has bucketloads of fatty acids; the body's pH drops dangerously low. By hyperventilating, the body reduces the carbon dioxide available to make carbonic acid, and raises the pH enough to keep one alive. Physicians call this "blowing off CO2."
Despite all the hype about global warming, the amount of carbon dioxide in the atmosphere is essentially nil. It has increased 30% since 1750, and it is wreaking havoc with the environment, but as far as the body is concerned, the air we breathe contains no CO2.
The partial pressure of CO2 at sea level is 0.3 torr.Your body normally keeps the CO2 at 40 torr in the arterial blood, more than 100 times greater than the atmosphere!
Enough science! Pant...gasp...gasp...pant....
Increase your ventilation, your acid goes down. Decrease your ventilation, acid goes up.
Lesson Number Two:
Ionized calcium concentration affects your muscles and nerves
While calcium is the most abundant mineral in your body, only ionized calcium has effects on nerve impulses and muscle contractility. Decrease the amount of ionized calcium and your nervous system becomes irritable. You may feel tingling. Muscles may go into spasm.
In severe cases, psychiatric changes can be seen with low ionized calcium levels.
The amount of calcium available in ionized form is directly dependent on the pH. If you raise the pH by lowering the acid, less ionized calcium is available to work. If you hyperventilate, you raise your pH.
Lesson Number Three:
Cerebral artery flow is dependent on the carbon dioxide concentration in the blood
You do not want to go to work. The alarm clock stuns you awake. Sunlight is peering through the blinds. You slap the snooze button as you pull the covers over your head.
The alarm growls again 10 minutes later; an arm reaches out from the covers, and hits the snooze alarm again. Your head remains cocooned.
The alarm racks your brain once again.
You get up, and your head throbs. Each beat of your heart pounds your temples. You have a vascular headache.
You did not drink last night. Your period was two weeks ago. You feel fine otherwise.
Increasing carbon dioxide in the blood increases blood flow to the brain. CO2 is a potent cerebral vasodilator. Conversely, lowering CO2 squeezes the cerebral arteries.
(Not too long ago trauma doctors routinely hyperventilated head trauma victims to reduce bloodflow to a brain swelling in the skull, to prevent brainstem herniation. It may have reduced bloodflow, but patients did not do well, and this is no longer recommended.)
Your cerebral arteries are clamping down as effectively as someone partially strangling you. Your adrenaline will surge. You will feel a sense of impending doom as the adrenaline surge triggers your "fight or flight" reaction.
Putting it all together:
Your body knows what it is doing, for the most part. You do not even think about your breathing. Once you start thinking about breathing, however, a cascade of events can be triggered.
You start to increase your ventilation. Your CO2 drops.
The world starts to close in a bit as your vision fades just a bit. Vision is highly dependent on good cerebral bloodflow. Notice how in the death scene, the fallen hero's eyes look unfocused, yet she can still hear and talk.
You release adrenaline now--your pulse rises from this hormonal rush. You shake, might even feel clammy. All this is a direct response to the adrenaline. It is a physiologic response. It is not just in your head.
Now things get worse. Your fear increases your breathing. Your available calcium now drops. Your hands and feet start tingling, and your hands go into painful spasm.
A crowd envelops you. Invariably some well-meaning bystander will offer this advice: "It's all in your head. Just relax."
Feeling like you're dying (and the feeling is very, very real), advice like this is counter-productive.
Eventually, the cerebral arteries no longer permit enough bloodflow to the brain to support consciousness. Out you go.
(You will wake up again--once unconscious, the cortex no longer pretends to be superior to the reptilian part of the brain, and your breathing will normalize.)
I used to have medical students deliberately hyperventilate to prove to them that these changes are real. I no longer do; the good old days when medical students willingly subjected themselves to a variety of barbaric exercises have since passed. I do not recommend that anyone try this at home without at first getting approval from your doctor. You can induce seizures and all kinds of fun things.