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Pinky and the Brain.
One day, the scientists at the lab brought in a new lab mouse, her name was 'Snowball.' Brain fell head over heals in love, then found himself asking Pinky for help in wooing her, since she had something like Pinky's IQ. Pretty funny, as the Brain had to say stuff like 'Narf'
"Say Narf!"
"No, Pinky, I'll never say such a stupid word"
He later said it, and she started to like Brain over Pinky, who she initially liked because he wasn't as geeky.
Then the next day, the scientists somehow zapped her with the same experiment used on the brain, and she suddenly became smarter than Brain, able to do math problems in seconds that he did in a month. Now, Pinky and the Brain must compete with Snowball in a race to take over the world. She's now an archnemesis.